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Research & Publications

Dr Roy Chowdhury is the clinical trial administrator of Saroj Gupta Cancer Centre and Research Institute, Thakurpukur, Kolkata. Here he plays a pivotal role in driving both clinical and academic research trials in the institute.
He is a keen researcher and collaborates on various projects with scientists from National Institute of Bio Medical Genomics (NIBMG), Kalyani, Indian Institute of Chemical Biology, Jadavpur, Kolkata and various departments of University of Calcutta.

At present he is involved in the following projects:

  • A prospective non-randomised trial of Squamous Cell Carcinoma of cervix uteri of stage IB2, IIA, IIB pretreated with three cycles of Neo Adjuvant Chemotherapy (NACT) followed by surgery after down-staging to stage IB1 followed by active surveillance. Dr N R Mondal, Dr R Roy Chowdhury, Dr Biman Chakrabarti, Dr T Chatterjee, Dr J Basak (Dept of Gynaecological Oncology SGCCRI)
  • Variation in human gene expression among women from four states of India: genomic correlates, gene regulation and impact on HPV16 related cervical cancer pathogenesis.              Dr Sharmila Sengupta, National Institute of Biomedical Genomics, Kalyani, Dr N R Mondal , Dr R Roy Chowdhury (Dept of Gynaeoncology), SGCCRI, Thakurpukur
  • Association of genetic polymorphism of matrix metalloproteinases (MMPs) and their expression in epithelial ovarian cancer. Dr Susri Ray Chaudhuri PhD (Research Associate), IICB, Dr Snehaswikta Swarnakar, Senior Scientist IICB, Dr Rahul Roy Chowdhury MRCOG, SGCCRI Thakurpukur [ ICMR funded project]
  • HPV 16 Methylome, methylation and gene expression status of host genes: influence on cervical cancer pathogenesis.- Dr Rahul Roy Chowdhury, SGCCRI and Dr Sharmila Sengupta NIBMG
  • A Phase II Clinical Study to evaluate the efficacy and safety of NRC – AN – 019 in cancer patients failing standard prior therapies – Dr Samir Bhattacharyya, SGCCRI, Dr R N Ghosh, Dr Arnab Gupta, Dr Saradindu Ghosh, Dr Rakesh Roy, Dr Rahul Roy Chowdhury.
  • HPV 16 Methylome, methylation and gene expression status of host genes: influence on cervical cancer pathogenesis.- Dr Rahul Roy Chowdhury, SGCCRI and Dr Sharmila Sengupta NIBMG

Ongoing Trial:

  • 1. A phase III multicentre trial of weekly induction chemotherapy followed by standard
    chemo-radiation versus standard chemo-radiation alone in patients with locally
    advanced cervical cancer [INTERLACE] – SITE PI in an International Academic Trial.
    Sponsor-University College London and Cancer Research, UK.
  • 2. Integrating Multi-Omics Data Using Big data analytic to infer optimal wellness
    trajectories for management of non-communicable disease (NCDs): cervical cancer as an
    exemplar – Co – I , Academic Trial, Flagship project of National Institute of Bio-medical
    Genomics, Sponsor: DBT

His recent publications include:

  • Das Ghosh D, Roy Chowdhury R, Roychoudhury S, EPV139/#616. TP53 mutations differentially affect
    prognosis of endometrial cancer: an in-silico approach International Journal of Gynecologic
    Cancer 2021;31:A85.
  • Mandal P, Bhattacharjee B, Sen S, Bhattacharya A, Saha SS, Chowdhury RR, Mondal NR, Chakrabarty
    B, Chatterjee T, Roy S, Sengupta S. Predominance of genomically defined A lineage of HPV16 over D
    lineage in Indian patients from eastern India with squamous cell carcinoma of the cervix in
    association with distinct oncogenic phenotypes. Transl Oncol. 2021 Oct 27;15(1):101256. doi:
    10.1016/j.tranon.2021.101256. Epub ahead of print. PMID: 34717279; PMCID: PMC8564679.
  • Kurtz JE, Gebski V, Sukhin V, Carey M, Kong I, Glasspool RM, Berek JS, de Paiva Batista M, Hall M,
    Kim JW, Yeoshoua E, Fujiwara N, Nam BH, Polleis S, Lee JY, Strojna A, Farrelly L, Schwameis R, Fossati
    R, Darlington AS, Lai CH, Wright AA, Rosenblat O, Harter P, Roxburgh P, Chowdhury RR, Chang TC,
    Paoletti X, Friedlander M; Gynecologic Cancer InterGroup (GCIG) symptom benefit committee.
    Incorporating patient centered benefits as endpoints in randomized trials of maintenance therapies
    in advanced ovarian cancer: A position paper from the GCIG symptom benefit committee. Gynecol
    Oncol. 2021 May;161(2):502-507. doi: 10.1016/j.ygyno.2021.02.018. Epub 2021 Feb 19. PMID:
  • Mandal P, Saha S S, Sen S, Bhattacharya A, Bhattacharya N P, Bucha S, Sinha M, Roy Chowdhury R,
    Mondal N R, Chakravarty B, Chatterjee T, Roy S, Chattapadhyay A, Sengupta S. Cervical cancer
    subtypes harbouring integrated and / or episomal HPV 16 portray distinct molecular phenotypes
    based on transcriptome profiling of mRNAs and miRNAs. Cell Death Discovery (2019)5:81.
  • Sen S, Mandal P, Bhattacharya A, Kundu S, Roy Chowdhury R, Mondal N, Chatterjee T Chakravarty
    B, Roy S, Sengupta S. (2017). Impact of viral and host DNA methylations on HPV16-related cervical
    cancer pathogenesis. Tumor Biology. 39. 101042831769979. 10.1177/1010428317699799.
  • Sweta Sharma Saha S, Roy Chowdhury R, Mondal NR, Roy S, Sengupta S. Expression signatures of
    HOX cluster genes in cervical cancer pathogenesis: Impact of human papillomavirus type 16
    oncoprotein E7. Oncotarget. 2017 Mar 28. doi: 10.18632/oncotarget.16619. [Epub ahead of print]
  • Das Ghosh D, Mukhopadhyay I, Bhattacharya A, Roy Chowdhury R, Mandal NR, Roy S, Sengupta S.
    Impact of genetic variations and transcriptional alterations of HLA class I genes on cervical cancer
    pathogenesis. Int. J. Cancer: 140, 2498–2508 (2017)
  • Chakrabarti B, Mondal NR, Chatterjee T, Roychowdhury R. Analysis of 58 Cases of GTT from 2000-
    2013 at A Tertiary Cancer Center in India. BAOJ Gynaec 1: 010.
  • Saha S S, Roy Chowdhury R, Mondal NR, Chakravarty B, Chatterjee T, Roy S, Sengupta S.
    Identification of genetic variation in the lnc RNA HOTAIR associated with HPV16-related cervical
    cancer pathogenesis. Cell Oncol. DOI 10.1007/s13402-016-0298-0.
  • S Ray Chaudhuri Guha, A Roy, I Chatterjee, R Roy Chowdhury, S Swarnakar. Landscape of Papillomavirus in human cancers: Prevention and therapeutic avenues. Book Chapter in Cancer-causing viruses and their inhibitors. S P Gupta and V Gautam Eds. CRC press; May 2014; 207- 242.
  • Mandal P, Bhattacharjee B, Das Ghosh D, Mondal NR, Roy Chowdhury R, et al. (2013) Differential Expression of HPV16 L2 Gene in Cervical Cancers Harboring Episomal HPV16 Genomes: Influence of Synonymous and Non-Coding Region Variations. PLoS ONE 8(6): e65647. doi:10.1371/journal.pone.0065647
  • Das Ghosh D, Bhattacharjee B, Sen S, Premi L, Mukhopadhyay I, Roy Chowdhury R, Roy S, Sengupta S. (2012) Some Novel Insights on HPV16 Related Cervical Cancer Pathogenesis Based on Analyses of LCR Methylation, Viral Load, E7 and E2/E4 Expressions. PLoS ONE 7(9): e44678. doi:10.1371/journal.pone.0044678
  • *Ray Chaudhuri (Guha) S, *Banerjee P, *Yadav DK, **Roy Chowdhury R, **Mondal NR, *Swarnakar S. Search for an alternative bio-marker for prognosis of Epithelial Ovarian Cancer – Poster presentation  (SPP 42) at the 1st International Meet on Cell Signaling Network (CeSiN 2012); 11 – 13
  • Epidemiology of Vulval Malignancy.
  • Chakrabarti Biman Kumar, Roy Chowdhury Rahul, Chatterjee Tanmoy, Mondal Nidhu Ranjan.
    Poster presented in the XX FIGO World Congress of Gynecology and Obstetrics. Rome 7 – 12  October 2012. ABT11 – Gyne-oncology DOI: 10.3252/
  • Guha S, Roy Chowdhury R (2007). A long-term study of women with normal colposcopy after referral with low-grade cytological abnormalities. BJOG: An International Journal of Obstetrics and Gynaecology 114 (4), 508–508. (doi:10.1111/j.1471-0528.2006.01253.x)
  • Bridging Links Between Long Noncoding RNA HOTAIR and HPV oncoprotein E7 in cervical Cancer Pathogenesis. Sweta Samanta, Paramita Mmandal, Rahul Roy chowdhury, Tamal Sadhukhan, Nidhu ranjan Mandal, Biman Chakravarty. Scientific Reports (Impact Factor: 5.58). 07/2015; 5:11724. DOI: 10.1038/srep11724 Source: PubMed

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